Clinical Use: Zinc sulfate is a medication used to treat or prevent zinc deficiency. Zinc is an essential mineral that plays a crucial role in various bodily functions, including immune function, wound healing, DNA synthesis, and cell division. Zinc deficiency can lead to a range of health problems, including impaired immune function, delayed wound healing, and growth retardation in children. Zinc sulfate supplementation helps to restore zinc levels in individuals with deficiency and may also be used in certain medical conditions where zinc supplementation is beneficial.

Indications:

• Treatment of zinc deficiency: Zinc sulfate tablets are indicated for individuals with confirmed zinc deficiency, either through laboratory testing or clinical assessment.
• Prevention of zinc deficiency: In individuals at risk of developing zinc deficiency due to dietary insufficiency, malabsorption syndromes, chronic illnesses, or other factors, zinc sulfate may be used as a preventive measure to maintain adequate zinc levels.

Contraindications:

• Hypersensitivity: Individuals with a known hypersensitivity or allergy to zinc sulfate or any of its components should avoid using zinc sulfate tablets.
• Wilson's disease: Zinc sulfate may exacerbate copper deficiency in individuals with Wilson's disease, a rare genetic disorder characterized by abnormal copper metabolism. Therefore, it is contraindicated in patients with Wilson's disease unless prescribed and monitored by a healthcare professional.

Adverse Reactions:

• Gastrointestinal upset: The most common adverse reactions associated with zinc sulfate supplementation include nausea, vomiting, diarrhea, and abdominal discomfort. These symptoms are usually mild and transient, resolving with continued use or dosage adjustment.
• Metallic taste: Some individuals may experience a metallic taste in the mouth while taking zinc sulfate tablets, which can affect taste perception and lead to decreased appetite.
• Allergic reactions: Rarely, allergic reactions such as rash, itching, swelling, or difficulty breathing may occur in individuals with hypersensitivity to zinc sulfate.

Dosage: The dosage of zinc sulfate tablets may vary depending on the severity of zinc deficiency and the individual's age, weight, and medical condition. The recommended dosage for adults and children over 12 years of age is typically 20 to 220 mg of elemental zinc per day, divided into two to three doses. For children aged 4 to 12 years, the recommended dosage is usually 10 to 20 mg of elemental zinc per day. Dosages for infants and toddlers should be determined based on weight and specific clinical indications, with guidance from a healthcare provider.